View source for 4hzl


==Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein==
<StructureSection load='4hzl' size='340' side='right'caption='[[4hzl]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Recombinant_Hepatitis_C_virus_H77(5'UTR-NS2)/JFH1_V787A,Q1247L Recombinant Hepatitis C virus H77(5'UTR-NS2)/JFH1_V787A,Q1247L]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HZL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzl OCA], [https://pdbe.org/4hzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hzl RCSB], [https://www.ebi.ac.uk/pdbsum/4hzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hzl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/F5BWY6_9HEPC F5BWY6_9HEPC] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Hepatitis C virus (HCV) envelope glycoprotein E2 has been considered as a major target for vaccine design. Epitope II, mapped between residues 427-446 within the E2 protein, elicits antibodies that are either neutralizing or nonneutralizing. The fundamental mechanism of antibody-mediated neutralization at epitope II remains to be defined at the atomic level. Here we report the crystal structure of the epitope II peptide in complex with a monoclonal antibody (mAb#8) capable of neutralizing HCV. The complex structure revealed that this neutralizing antibody engages epitope II via interactions with both the C-terminal alpha-helix and the N-terminal loop using a bifurcated mode of action. Our structural insights into the key determinants for the antibody-mediated neutralization may contribute to the immune prophylaxis of HCV infection and the development of an effective HCV vaccine.

Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus.,Deng L, Zhong L, Struble E, Duan H, Ma L, Harman C, Yan H, Virata-Theimer ML, Zhao Z, Feinstone S, Alter H, Zhang P Proc Natl Acad Sci U S A. 2013 Apr 15. PMID:23589879<ref>PMID:23589879</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4hzl" style="background-color:#fffaf0;"></div>

==See Also==
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Deng L]]
[[Category: Zhang P]]