View source for 4ibc


==Ebola virus VP35 bound to small molecule==
<StructureSection load='4ibc' size='340' side='right'caption='[[4ibc]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ibc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IBC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.745&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12G:{4-[(2R)-3-(2-CHLOROBENZOYL)-2-(2-CHLOROPHENYL)-4-HYDROXY-5-OXO-2,5-DIHYDRO-1H-PYRROL-1-YL]PHENYL}ACETIC+ACID'>12G</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ibc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ibc OCA], [https://pdbe.org/4ibc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ibc RCSB], [https://www.ebi.ac.uk/pdbsum/4ibc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ibc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Ebola virus - Mayinga, Zaire, 1976]]
[[Category: Large Structures]]
[[Category: Amarasinghe GK]]
[[Category: Binning JM]]
[[Category: Borek DM]]
[[Category: Brown CS]]
[[Category: Leung DW]]
[[Category: Otwinowski Z]]
[[Category: Peterson DS]]
[[Category: Ramanan P]]
[[Category: Stubbs AJ]]
[[Category: Xu W]]