View source for 4iii


==Lambda-[Ru(TAP)2(11-Cl-dppz)] with a DNA decamer at atomic resolution==
<StructureSection load='4iii' size='340' side='right'caption='[[4iii]], [[Resolution|resolution]] 1.02&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4iii]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4III OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4III FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.02&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=RCZ:RU(TAP)2(CL-DPPZ)+COMPLEX'>RCZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iii OCA], [https://pdbe.org/4iii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iii RCSB], [https://www.ebi.ac.uk/pdbsum/4iii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iii ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the ruthenium DNA 'light-switch' complex Lambda-[Ru(TAP)2(11-Cl-dppz)](2+) (TAP=tetraazaphenanthrene, dppz=dipyrido[3,2-a':2',3'-c]phenazine) bound to the oligonucleotide duplex d(TCGGCGCCGA)2 is reported. The synthesis of the racemic ruthenium complex is described for the first time, and the racemate was used in this study. The crystal structure, at atomic resolution (1.0 A), shows one ligand as a wedge in the minor groove, resulting in the 51( degrees ) kinking of the double helix, as with the parent Lambda-[Ru(TAP)2(dppz)](2+). Each complex binds to one duplex by intercalation of the dppz ligand and also by semi-intercalation of one of the orthogonal TAP ligands into a second symmetrically equivalent duplex. The 11-chloro substituent binds with the major component (66%) oriented with the 11-chloro substituent on the purine side of the terminal step of the duplex.

Preferred orientation in an angled intercalation site of a chloro-substituted {Lambda}-[Ru(TAP)2(dppz)]2+ complex bound to d(TCGGCGCCGA)2.,Hall JP, Beer H, Buchner K, Cardin DJ, Cardin CJ Philos Trans A Math Phys Eng Sci. 2013 Jun 17;371(1995):20120525. doi:, 10.1098/rsta.2012.0525. Print 2013. PMID:23776304<ref>PMID:23776304</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4iii" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Cardin CJ]]
[[Category: Hall JP]]