View source for 4iip


==Legionella pneumophila effector==
<StructureSection load='4iip' size='340' side='right'caption='[[4iip]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4iip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iip OCA], [https://pdbe.org/4iip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iip RCSB], [https://www.ebi.ac.uk/pdbsum/4iip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iip ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIDD_LEGPH SIDD_LEGPH] Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as an adenosine monophosphate-protein hydrolase (de-AMPylase) by mediating the hydrolysis of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby releasing RAB1B from bacterial phagosomes and rendering RAB1B accessible for inactivation by LepB. De-AMPylation of RAB1B cannot take place when LidA is bound to RAB1B.<ref>PMID:21734656</ref> <ref>PMID:21680813</ref> <ref>PMID:22228731</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
[[Category: Chen Y]]
[[Category: Hierro A]]
[[Category: Machner MP]]
[[Category: Neunuebel MR]]
[[Category: Rojas AL]]
[[Category: Tascon I]]