View source for 4iqa


==Crystal Structure Analysis of the E228L Mutant of Human CLIC1==
<StructureSection load='4iqa' size='340' side='right'caption='[[4iqa]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4iqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IQA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqa OCA], [https://pdbe.org/4iqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iqa RCSB], [https://www.ebi.ac.uk/pdbsum/4iqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref> 

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Achilonu IA]]
[[Category: Cross MO]]
[[Category: Dirr HW]]
[[Category: Fanucchi S]]
[[Category: Fernandes MA]]