View source for 4it7


==Crystal structure of Al-CPI==
<StructureSection load='4it7' size='340' side='right'caption='[[4it7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4it7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ascaris_lumbricoides Ascaris lumbricoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IT7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4it7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it7 OCA], [https://pdbe.org/4it7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4it7 RCSB], [https://www.ebi.ac.uk/pdbsum/4it7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4it7 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Immunosuppression associated with infections of nematode parasites has been documented. Cysteine protease inhibitor (CPI) released by the nematode parasites is identified as one of the major modulators of host immune response. In this report, we demonstrated that the recombinant CPI protein of Ascaris lumbricoides (Al-CPI) strongly inhibited the activities of cathepsin L, C, S, and showed weaker effect to cathepsin B. Crystal structure of Al-CPI was determined to 2.1 A resolution. Two segments of Al-CPI, loop 1 and loop 2, were proposed as the key structure motifs responsible for Al-CPI binding with proteases and its inhibitory activity. Mutations at loop 1 and loop 2 abrogated the protease inhibition activity to various extents. These results provide the molecular insight into the interaction between the nematode parasite and its host and will facilitate the development of anthelmintic agents or design of anti-autoimmune disease drugs.

Structural Basis for the Immunomodulatory Function of Cysteine Protease Inhibitor from Human Roundworm Ascaris lumbricoides.,Mei G, Dong J, Li Z, Liu S, Liu Y, Sun M, Liu G, Su Z, Liu J PLoS One. 2014 Apr 29;9(4):e96069. doi: 10.1371/journal.pone.0096069. eCollection, 2014. PMID:24781326<ref>PMID:24781326</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 4it7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Ascaris lumbricoides]]
[[Category: Large Structures]]
[[Category: Liu J]]
[[Category: Liu SL]]
[[Category: Mei GQ]]
[[Category: Sun MZ]]