View source for 4ivq


==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with IN43/5==
<StructureSection load='4ivq' size='340' side='right'caption='[[4ivq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ivq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IVQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I43:6-[3-HYDROXY-2-(HYDROXYMETHYL)PROP-1-EN-1-YL]-4-METHOXY-1,5-DIMETHYLPYRIMIDIN-2(1H)-ONE'>I43</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ivq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ivq OCA], [https://pdbe.org/4ivq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ivq RCSB], [https://www.ebi.ac.uk/pdbsum/4ivq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ivq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).

==See Also==
*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Large Structures]]
[[Category: Novakovic I]]
[[Category: Pernot L]]
[[Category: Perozzo R]]
[[Category: Raic-Malic S]]
[[Category: Scapozza L]]
[[Category: Westermaier Y]]