View source for 4iy2


==Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4==
<StructureSection load='4iy2' size='340' side='right'caption='[[4iy2]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4iy2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IY2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iy2 OCA], [https://pdbe.org/4iy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iy2 RCSB], [https://www.ebi.ac.uk/pdbsum/4iy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iy2 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN] Familial primary hypomagnesemia with normocalcuria and normocalcemia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Accardi A]]
[[Category: Corral-Rodriguez MA]]
[[Category: Diercks T]]
[[Category: Encinar JA]]
[[Category: Ereno-Orbea J]]
[[Category: Gomez-Garcia I]]
[[Category: Martinez-Cruz LA]]
[[Category: Muller D]]
[[Category: Oyenarte I]]
[[Category: Spiwok V]]
[[Category: Stuiver M]]
[[Category: Terashima H]]