View source for 4iyp


==structure of the nPP2Ac-alpha4 complex==
<StructureSection load='4iyp' size='340' side='right'caption='[[4iyp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4iyp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IYP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.797&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyp OCA], [https://pdbe.org/4iyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iyp RCSB], [https://www.ebi.ac.uk/pdbsum/4iyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyp ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IGBP1_HUMAN IGBP1_HUMAN] Agenesis of the corpus callosum - intellectual deficit - coloboma - micrognathia. Defects in IGBP1 are the cause of mental retardation syndromic X-linked type 28 (MRXS28) [MIM:[https://omim.org/entry/300472 300472]; also known as agenesis of the corpus callosum with mental retardation, ocular coloboma and micrognathia. A syndrome that is characterized by coloboma of the iris and optic nerve, severe retrognathia, intellectual deficit, and agenesis of the corpus callosum.<ref>PMID:14556245</ref> 
== Function ==
[https://www.uniprot.org/uniprot/IGBP1_HUMAN IGBP1_HUMAN] Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits.<ref>PMID:19818709</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The catalytic subunit of protein phosphatase 2A (PP2Ac) is stabilized in a latent form by alpha4, a regulatory protein essential for cell survival and biogenesis of all PP2A complexes. Here we report the structure of alpha4 bound to the N-terminal fragment of PP2Ac. This structure suggests that alpha4 binding to the full-length PP2Ac requires local unfolding near the active site, which perturbs the scaffold subunit binding site at the opposite surface via allosteric relay. These changes stabilize an inactive conformation of PP2Ac and convert oligomeric PP2A complexes to the alpha4 complex upon perturbation of the active site. The PP2Ac-alpha4 interface is essential for cell survival and sterically hinders a PP2A ubiquitination site, important for the stability of cellular PP2Ac. Our results show that alpha4 is a scavenger chaperone that binds to and stabilizes partially folded PP2Ac for stable latency, and reveal a mechanism by which alpha4 regulates cell survival, and biogenesis and surveillance of PP2A holoenzymes.

Structural basis of protein phosphatase 2A stable latency.,Jiang L, Stanevich V, Satyshur KA, Kong M, Watkins GR, Wadzinski BE, Sengupta R, Xing Y Nat Commun. 2013;4:1699. doi: 10.1038/ncomms2663. PMID:23591866<ref>PMID:23591866</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4iyp" style="background-color:#fffaf0;"></div>

==See Also==
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jiang L]]
[[Category: Satyshur KA]]
[[Category: Stanevich V]]
[[Category: Xing Y]]