View source for 4jbk


==Molecular basis for abrogation of activation of pro-inflammatory cytokines==
<StructureSection load='4jbk' size='340' side='right'caption='[[4jbk]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jbk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.963&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbk OCA], [https://pdbe.org/4jbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbk RCSB], [https://www.ebi.ac.uk/pdbsum/4jbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Cheng G]]
[[Category: Crowley C]]
[[Category: Ding W]]
[[Category: Hung L-W]]
[[Category: Liu Z-J]]
[[Category: Ni X]]
[[Category: Ru H]]
[[Category: Shaw N]]
[[Category: Zhao L]]