View source for 4jby


==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with F-SK78==
<StructureSection load='4jby' size='340' side='right'caption='[[4jby]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jby]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FSK:6-[(1Z)-3-FLUORO-2-(HYDROXYMETHYL)PROP-1-EN-1-YL]-1,5-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>FSK</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jby OCA], [https://pdbe.org/4jby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jby RCSB], [https://www.ebi.ac.uk/pdbsum/4jby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jby ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).

==See Also==
*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Large Structures]]
[[Category: Novakovic I]]
[[Category: Pernot L]]
[[Category: Perozzo R]]
[[Category: Raic-Malic S]]
[[Category: Scapozza L]]
[[Category: Westermaier Y]]