View source for 4jd8


==Racemic-[Ru(phen)2(dppz)]2+] bound to synthetic DNA at high resolution==
<StructureSection load='4jd8' size='340' side='right'caption='[[4jd8]], [[Resolution|resolution]] 1.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jd8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JD8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.16&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0TN:DELTA-RU(PHEN)2(DPPZ)+COMPLEX'>0TN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=RKP:LAMBDA-RU(PHEN)2(DPPZ)+COMPLEX'>RKP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jd8 OCA], [https://pdbe.org/4jd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jd8 RCSB], [https://www.ebi.ac.uk/pdbsum/4jd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jd8 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report an atomic resolution X-ray crystal structure containing both enantiomers of rac-[Ru(phen)2dppz](2+) with the d(ATGCAT)2 DNA duplex (phen = phenanthroline; dppz = dipyridophenazine). The first example of any enantiomeric pair crystallized with a DNA duplex shows different orientations of the Lambda and Delta binding sites, separated by a clearly defined structured water monolayer. Job plots show that the same species is present in solution. Each enantiomer is bound at a TG/CA step and shows intercalation from the minor groove. One water molecule is directly located on one phenazine N atom in the Delta-enantiomer only.

X-ray Crystal Structure of rac-[Ru(phen)2dppz](2+) with d(ATGCAT)2 Shows Enantiomer Orientations and Water Ordering.,Hall JP, Cook D, Morte SR, McIntyre P, Buchner K, Beer H, Cardin DJ, Brazier JA, Winter G, Kelly JM, Cardin CJ J Am Chem Soc. 2013 Aug 28;135(34):12652-9. doi: 10.1021/ja403590e. Epub 2013 Aug, 14. PMID:23875832<ref>PMID:23875832</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4jd8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Cardin CJ]]
[[Category: Cook DS]]
[[Category: Hall JP]]