View source for 4jko


==Crystal structure of a catalytic mutant of Axe2 (Axe2_S15A), an acetylxylan esterase from Geobacillus stearothermophilus==
<StructureSection load='4jko' size='340' side='right'caption='[[4jko]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jko]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JKO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jko OCA], [https://pdbe.org/4jko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jko RCSB], [https://www.ebi.ac.uk/pdbsum/4jko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jko ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AXE2_GEOSE AXE2_GEOSE] Acetylxylan esterase involved in the degradation of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Cleaves acetyl side groups from the xylose backbone units of the hemicellulolytic polymer xylan and xylo-oligosaccharides. Hydrolyzes about 20%-30% of the available acetyl groups on fully acetylated birch wood xylan. Completely deacetylates xylobiose peracetate (fully acetylated), and is active on both the alpha- and beta-forms of the sugar. Also hydrolyzes fully acetylated methyl-beta-D-xylopyranoside and methyl-beta-D-glucopyranoside, and the synthetic substrates 2-naphthyl acetate, 4-nitrophenyl acetate, 4-methylumbelliferyl acetate, and phenyl acetate.<ref>PMID:21994937</ref> 

==See Also==
*[[Acetylxylan esterase 3D structures|Acetylxylan esterase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Large Structures]]
[[Category: Alalouf O]]
[[Category: Alhassid A]]
[[Category: Azulay D]]
[[Category: Belrahli H]]
[[Category: Chayan NE]]
[[Category: Govada L]]
[[Category: Lansky S]]
[[Category: Shoham G]]
[[Category: Shoham Y]]
[[Category: Solomon V]]