View source for 4jt3


==Crystal Structure of TTK kinase domain with an inhibitor: 400740==
<StructureSection load='4jt3' size='340' side='right'caption='[[4jt3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JT3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PH:2-PHENYL-N-[3-(3-SULFAMOYLPHENYL)-2H-INDAZOL-5-YL]ACETAMIDE'>1PH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jt3 OCA], [https://pdbe.org/4jt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jt3 RCSB], [https://www.ebi.ac.uk/pdbsum/4jt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jt3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> 

==See Also==
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Awrey DE]]
[[Category: Chirgadze NY]]
[[Category: Feher M]]
[[Category: Harris-Brandts M]]
[[Category: Qiu W]]