View source for 4jun


==Crystal structure of H5N1 influenza virus hemagglutinin, clade 5==
<StructureSection load='4jun' size='340' side='right'caption='[[4jun]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jun]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Guangxi/2396/2004(H5N1)) Influenza A virus (A/duck/Guangxi/2396/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JUN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3398&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jun OCA], [https://pdbe.org/4jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jun RCSB], [https://www.ebi.ac.uk/pdbsum/4jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jun ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q2F4V6_9INFA Q2F4V6_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS000149_004_327643]

==See Also==
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Coop T]]
[[Category: DuBois RM]]
[[Category: Heath RJ]]
[[Category: Reddivari M]]
[[Category: Russell CJ]]
[[Category: White SW]]
[[Category: Zaraket H]]