View source for 4jyk


==Structure of E. coli Transcriptional Regulator RutR with bound uracil==
<StructureSection load='4jyk' size='340' side='right'caption='[[4jyk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jyk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JYK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyk OCA], [https://pdbe.org/4jyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jyk RCSB], [https://www.ebi.ac.uk/pdbsum/4jyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jyk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RUTR_ECOLI RUTR_ECOLI] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).<ref>PMID:16540542</ref> <ref>PMID:17919280</ref> 

==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Almo SC]]
[[Category: Cooper DR]]
[[Category: Knapik AA]]
[[Category: Minor W]]
[[Category: Osinski T]]
[[Category: Petkowski JJ]]
[[Category: Porebski PJ]]