View source for 4kgn


==Crystal structure of a tRNA (cytidine(34)-2'-O)-methyltransferase bound to S-adenosyl homocysteine==
<StructureSection load='4kgn' size='340' side='right' caption='[[4kgn]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4kgn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Burp1 Burp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KGN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e5y|3e5y]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BURPS1710b_0668, trmL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=320372 BURP1])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(cytidine(34)-2'-O)-methyltransferase tRNA (cytidine(34)-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.207 2.1.1.207] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgn OCA], [http://pdbe.org/4kgn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kgn RCSB], [http://www.ebi.ac.uk/pdbsum/4kgn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kgn ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/Q3JWH1_BURP1 Q3JWH1_BURP1]] Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity).[HAMAP-Rule:MF_01885] 

==See Also==
*[[TRNA methyltransferase|TRNA methyltransferase]]
__TOC__
</StructureSection>
[[Category: Burp1]]
[[Category: Structural genomic]]
[[Category: Half-site occupancy]]
[[Category: National institute for allergy and infectious disease]]
[[Category: Niaid]]
[[Category: S-adenosyl-methionine-dependent]]
[[Category: S-adenosylhomocysteine]]
[[Category: Sah]]
[[Category: Sam]]
[[Category: Ssgcid]]
[[Category: Transferase]]
[[Category: Trefoil protein knot]]
[[Category: Trna methyltransferase]]