View source for 4ksc


==Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain==
<StructureSection load='4ksc' size='340' side='right'caption='[[4ksc]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ksc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KSC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ksc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksc OCA], [https://pdbe.org/4ksc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ksc RCSB], [https://www.ebi.ac.uk/pdbsum/4ksc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Caya A]]
[[Category: Chang G]]
[[Category: Cregger C]]
[[Category: Doshi R]]
[[Category: Falson P]]
[[Category: Govaerts C]]
[[Category: Grimard V]]
[[Category: Lee C-W]]
[[Category: Martinez L]]
[[Category: Pardon E]]
[[Category: Steyaert J]]
[[Category: Swartz DJ]]
[[Category: Szewczyk P]]
[[Category: Urbatsch I]]
[[Category: Villaluz M]]
[[Category: Ward A]]