View source for 4kva


==GTPase domain of Septin 10 from Schistosoma mansoni in complex with GTP==
<StructureSection load='4kva' size='340' side='right'caption='[[4kva]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4kva]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KVA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kva OCA], [https://pdbe.org/4kva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kva RCSB], [https://www.ebi.ac.uk/pdbsum/4kva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kva ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SEP10_SCHMA SEP10_SCHMA] Filament-forming GTP-binding protein. Lacks GTPase activity, which is likely due to absence of an essential threonine residue important for hydrolytic activity in septins. May be involved in membrane remodeling, potentially by its nucleotide-dependent cellular membrane association/dissociation ability (PubMed:24464615). Able to bind to phosphatidylinositol-4,5-bisphosphate (PIP2)-containing giant unilamellar vesicles (GUVs), which serve as a model of biological membranes. Self-assembles into ordered cage-like structures on the vesicle membrane. Binds also to 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS)-containing vesicles suggesting the requirement for negatively charged membranes. Is also able to promote deformation of the GUVs (PubMed:27687162).<ref>PMID:24464615</ref> <ref>PMID:27687162</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schistosoma mansoni]]
[[Category: Araujo APU]]
[[Category: Brandao-Neto J]]
[[Category: Demarco R]]
[[Category: Garratt RC]]
[[Category: Pereira HM]]
[[Category: Santos YV]]
[[Category: Zeraik AE]]