View source for 4kzz


==Rabbit 40S ribosomal subunit in complex with mRNA, initiator tRNA and eIF1A==
<StructureSection load='4kzz' size='340' side='right'caption='[[4kzz]], [[Resolution|resolution]] 7.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4kzz]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 7.0305&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzz OCA], [https://pdbe.org/4kzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kzz RCSB], [https://www.ebi.ac.uk/pdbsum/4kzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IF1AX_HUMAN IF1AX_HUMAN] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
During translation initiation in eukaryotes, the small ribosomal subunit binds messenger RNA at the 5' end and scans in the 5' to 3' direction to locate the initiation codon, form the 80S initiation complex and start protein synthesis. This simple, yet intricate, process is guided by multiple initiation factors. Here we determine the structures of three complexes of the small ribosomal subunit that represent distinct steps in mammalian translation initiation. These structures reveal the locations of eIF1, eIF1A, mRNA and initiator transfer RNA bound to the small ribosomal subunit and provide insights into the details of translation initiation specific to eukaryotes. Conformational changes associated with the captured functional states reveal the dynamics of the interactions in the P site of the ribosome. These results have functional implications for the mechanism of mRNA scanning.

The initiation of mammalian protein synthesis and mRNA scanning mechanism.,Lomakin IB, Steitz TA Nature. 2013 Jul 21. doi: 10.1038/nature12355. PMID:23873042<ref>PMID:23873042</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4kzz" style="background-color:#fffaf0;"></div>

==See Also==
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Synthetic construct]]
[[Category: Lomakin IB]]
[[Category: Steitz TA]]