View source for 4ld8


==Crystal Structure of Dimeric Sudan Virus VP40==
<StructureSection load='4ld8' size='340' side='right'caption='[[4ld8]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ld8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sudan_ebolavirus Sudan ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LD8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ld8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ld8 OCA], [https://pdbe.org/4ld8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ld8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ld8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ld8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP40_EBOSU VP40_EBOSU] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication (By similarity).
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</StructureSection>
[[Category: Large Structures]]
[[Category: Sudan ebolavirus]]
[[Category: Ableson DM]]
[[Category: Bornholdt ZA]]
[[Category: Saphire EO]]