View source for 4ldc


==Crystal Structure of DOC2B C2B domain==
<StructureSection load='4ldc' size='340' side='right'caption='[[4ldc]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ldc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.264&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldc OCA], [https://pdbe.org/4ldc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldc RCSB], [https://www.ebi.ac.uk/pdbsum/4ldc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOC2B_RAT DOC2B_RAT] Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.<ref>PMID:18596155</ref> <ref>PMID:20150444</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Almagor L]]
[[Category: Giladi M]]
[[Category: Hirsch JA]]