View source for 4lk2


==Crystal structure of RNA splicing effector Prp5==
<StructureSection load='4lk2' size='340' side='right'caption='[[4lk2]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LK2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lk2 OCA], [https://pdbe.org/4lk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4lk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lk2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRP5_YEAST PRP5_YEAST] ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.<ref>PMID:8405998</ref> <ref>PMID:8065365</ref> <ref>PMID:8969184</ref> <ref>PMID:8969185</ref> <ref>PMID:8622683</ref> <ref>PMID:11927574</ref> <ref>PMID:14610285</ref> <ref>PMID:16314500</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Li J]]
[[Category: Xu Y]]
[[Category: Yang F]]
[[Category: Zhang Z-M]]
[[Category: Zhou J]]