View source for 4lkx


==Humanized antibody 4B12 Fab complexed with a CemX segment==
<StructureSection load='4lkx' size='340' side='right'caption='[[4lkx]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lkx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LKX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkx OCA], [https://pdbe.org/4lkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lkx RCSB], [https://www.ebi.ac.uk/pdbsum/4lkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lkx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6GMX6_HUMAN Q6GMX6_HUMAN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
IgE mediates hypersensitivity reactions responsible for most allergic diseases, which affect 20-40% of the population in developed countries. A 52-residue domain of membrane-bound IgE (mIgE) called CepsilonmX is currently a target for developing therapeutic antibodies; however, its structure is unknown. Here we show that two antibodies with therapeutic potential in IgE-mediated allergic diseases, which can cause cytolytic effects on mIgE-expressing B lymphocytes and downregulate IgE production, target different conformations of an intrinsically disordered region (IDR) in the extracellular CepsilonmX domain. We provide an important example of antibodies targeting an extracellular IDR of a receptor on the surface of intended target cells. We also provide fundamental structural characteristics unique to human mIgE, which may stimulate further studies to investigate whether other monoclonal antibodies (mAbs) targeting intrinsically disordered peptide segments or vaccine-like products targeting IDRs of a membrane protein can be developed.

Two potential therapeutic antibodies bind to a peptide segment of membrane-bound IgE in different conformations.,Chu HM, Wright J, Chan YH, Lin CJ, Chang TW, Lim C Nat Commun. 2014;5:3139. doi: 10.1038/ncomms4139. PMID:24457896<ref>PMID:24457896</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4lkx" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chan YH]]
[[Category: Chang TW]]
[[Category: Chu HM]]
[[Category: Lim C]]
[[Category: Lin CJ]]
[[Category: Wright J]]