View source for 4lm6


==Light harvesting complex PC612 from the cryptophyte Hemiselmis virescens M1635==
<StructureSection load='4lm6' size='340' side='right'caption='[[4lm6]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lm6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hemiselmis_virescens Hemiselmis virescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LM6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene>, <scene name='pdbligand=DBV:15,16-DIHYDROBILIVERDIN'>DBV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lm6 OCA], [https://pdbe.org/4lm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lm6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lm6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHEB_HEMVI PHEB_HEMVI] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Observation of coherent oscillations in the 2D electronic spectra (2D ES) of photosynthetic proteins has led researchers to ask whether nontrivial quantum phenomena are biologically significant. Coherent oscillations have been reported for the soluble light-harvesting phycobiliprotein (PBP) antenna isolated from cryptophyte algae. To probe the link between spectral properties and protein structure, we determined crystal structures of three PBP light-harvesting complexes isolated from different species. Each PBP is a dimer of alphabeta subunits in which the structure of the alphabeta monomer is conserved. However, we discovered two dramatically distinct quaternary conformations, one of which is specific to the genus Hemiselmis. Because of steric effects emerging from the insertion of a single amino acid, the two alphabeta monomers are rotated by approximately 73 degrees to an "open" configuration in contrast to the "closed" configuration of other cryptophyte PBPs. This structural change is significant for the light-harvesting function because it disrupts the strong excitonic coupling between two central chromophores in the closed form. The 2D ES show marked cross-peak oscillations assigned to electronic and vibrational coherences in the closed-form PC645. However, such features appear to be reduced, or perhaps absent, in the open structures. Thus cryptophytes have evolved a structural switch controlled by an amino acid insertion to modulate excitonic interactions and therefore the mechanisms used for light harvesting.

Single-residue insertion switches the quaternary structure and exciton states of cryptophyte light-harvesting proteins.,Harrop SJ, Wilk KE, Dinshaw R, Collini E, Mirkovic T, Teng CY, Oblinsky DG, Green BR, Hoef-Emden K, Hiller RG, Scholes GD, Curmi PM Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2666-75. doi:, 10.1073/pnas.1402538111. Epub 2014 Jun 16. PMID:24979784<ref>PMID:24979784</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4lm6" style="background-color:#fffaf0;"></div>

==See Also==
*[[Phycocyanin|Phycocyanin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Hemiselmis virescens]]
[[Category: Large Structures]]
[[Category: Curmi PMG]]
[[Category: Harrop SJ]]
[[Category: Wilk KE]]