View source for 4lms


==Light harvesting complex PC645 from the cryptophyte Chroomonas sp. CCMP270==
<StructureSection load='4lms' size='340' side='right'caption='[[4lms]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lms]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chroomonas_sp. Chroomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LMS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene>, <scene name='pdbligand=DBV:15,16-DIHYDROBILIVERDIN'>DBV</scene>, <scene name='pdbligand=M1V:MESOBILIVERDIN+IX(ALPHA)'>M1V</scene>, <scene name='pdbligand=MEN:N-METHYL+ASPARAGINE'>MEN</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lms OCA], [https://pdbe.org/4lms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lms RCSB], [https://www.ebi.ac.uk/pdbsum/4lms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lms ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHEA1_CHRS2 PHEA1_CHRS2] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Observation of coherent oscillations in the 2D electronic spectra (2D ES) of photosynthetic proteins has led researchers to ask whether nontrivial quantum phenomena are biologically significant. Coherent oscillations have been reported for the soluble light-harvesting phycobiliprotein (PBP) antenna isolated from cryptophyte algae. To probe the link between spectral properties and protein structure, we determined crystal structures of three PBP light-harvesting complexes isolated from different species. Each PBP is a dimer of alphabeta subunits in which the structure of the alphabeta monomer is conserved. However, we discovered two dramatically distinct quaternary conformations, one of which is specific to the genus Hemiselmis. Because of steric effects emerging from the insertion of a single amino acid, the two alphabeta monomers are rotated by approximately 73 degrees to an "open" configuration in contrast to the "closed" configuration of other cryptophyte PBPs. This structural change is significant for the light-harvesting function because it disrupts the strong excitonic coupling between two central chromophores in the closed form. The 2D ES show marked cross-peak oscillations assigned to electronic and vibrational coherences in the closed-form PC645. However, such features appear to be reduced, or perhaps absent, in the open structures. Thus cryptophytes have evolved a structural switch controlled by an amino acid insertion to modulate excitonic interactions and therefore the mechanisms used for light harvesting.

Single-residue insertion switches the quaternary structure and exciton states of cryptophyte light-harvesting proteins.,Harrop SJ, Wilk KE, Dinshaw R, Collini E, Mirkovic T, Teng CY, Oblinsky DG, Green BR, Hoef-Emden K, Hiller RG, Scholes GD, Curmi PM Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2666-75. doi:, 10.1073/pnas.1402538111. Epub 2014 Jun 16. PMID:24979784<ref>PMID:24979784</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4lms" style="background-color:#fffaf0;"></div>

==See Also==
*[[Phycocyanin|Phycocyanin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chroomonas sp]]
[[Category: Large Structures]]
[[Category: Curmi PMG]]
[[Category: Harrop SJ]]
[[Category: Wilk KE]]