View source for 4lrg


==Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide==
<StructureSection load='4lrg' size='340' side='right'caption='[[4lrg]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lrg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1XB:2-[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-[1,2]OXAZOLO[5,4-C]THIENO[2,3-E]AZEPIN-6-YL]ACETAMIDE'>1XB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrg OCA], [https://pdbe.org/4lrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrg RCSB], [https://www.ebi.ac.uk/pdbsum/4lrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrg ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Albrecht B]]
[[Category: Audia J]]
[[Category: Bellon S]]
[[Category: Bergeron L]]
[[Category: Birudukota S]]
[[Category: Bryant B]]
[[Category: Cote A]]
[[Category: Gehling V]]
[[Category: Harmange J-C]]
[[Category: Hewitt M]]
[[Category: Jayaram H]]
[[Category: Joshi S]]
[[Category: Leblanc Y]]
[[Category: Mertz J]]
[[Category: Nandana BS]]
[[Category: Nasveschuk C]]
[[Category: Pardo E]]
[[Category: Poy F]]
[[Category: Ravichandran S]]
[[Category: Sandy P]]
[[Category: Sims R]]
[[Category: Taylor A]]
[[Category: Vaswani R]]
[[Category: Yellapuntala S]]