View source for 4lun


==Structure of the N-terminal mIF4G domain from S. cerevisiae Upf2, a protein involved in the degradation of mRNAs containing premature stop codons==
<StructureSection load='4lun' size='340' side='right'caption='[[4lun]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LUN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.641&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lun OCA], [https://pdbe.org/4lun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lun RCSB], [https://www.ebi.ac.uk/pdbsum/4lun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lun ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NMD2_YEAST NMD2_YEAST] Involved in nonsense-mediated decay of mRNAs containing premature stop codons. It interacts, via its C-terminus, with NAM7/UPF1. Could be involved in determining the efficiency of translational termination or reinitiation or factors involved in the initial assembly of an initiation- and termination-competent mRNP.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Courreux PD]]
[[Category: Fourati Z]]
[[Category: Graille M]]
[[Category: He F]]
[[Category: Jacobson A]]
[[Category: Kervestin S]]
[[Category: Millan C]]
[[Category: Roy B]]
[[Category: Uson I]]
[[Category: Van Tilbeurgh H]]