View source for 4m3g


==Rapid and efficient design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging and linking approaches==
<StructureSection load='4m3g' size='340' side='right'caption='[[4m3g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4m3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M3G FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2G1:4-(2-METHYL-1,3-THIAZOL-4-YL)-N-(3,3,3-TRIFLUOROPROPYL)BENZENESULFONAMIDE'>2G1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m3g OCA], [https://pdbe.org/4m3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m3g RCSB], [https://www.ebi.ac.uk/pdbsum/4m3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m3g ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> 

==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Baulard A]]
[[Category: Blondiaux N]]
[[Category: Brodin P]]
[[Category: Crauste C]]
[[Category: Deprez B]]
[[Category: Flipo M]]
[[Category: Leroux F]]
[[Category: Malaquin S]]
[[Category: Piveteau C]]
[[Category: Sperandio O]]
[[Category: Villemagne B]]
[[Category: Villeret V]]
[[Category: Villoutreix B]]
[[Category: Willand N]]
[[Category: Wintjens R]]
[[Category: Wohlkonig A]]