View source for 4m3p


==Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine==
<StructureSection load='4m3p' size='340' side='right'caption='[[4m3p]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4m3p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M3P FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.895&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HCS:2-AMINO-4-MERCAPTO-BUTYRIC+ACID'>HCS</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m3p OCA], [https://pdbe.org/4m3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m3p RCSB], [https://www.ebi.ac.uk/pdbsum/4m3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m3p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BHMT1_HUMAN BHMT1_HUMAN] Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Diamond CE]]
[[Category: Garrow TA]]
[[Category: Jiracek J]]
[[Category: Jungwirth P]]
[[Category: Koutmos M]]
[[Category: Mladkova J]]
[[Category: Paterova J]]
[[Category: Tryon K]]
[[Category: Yamada K]]