View source for 4ma6


==Crystal structure of Ara h 8 with Epicatechin bound==
<StructureSection load='4ma6' size='340' side='right'caption='[[4ma6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ma6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arachis_hypogaea Arachis hypogaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MA6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=28E:(2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-2H-CHROMENE-3,5,7-TRIOL'>28E</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ma6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ma6 OCA], [https://pdbe.org/4ma6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ma6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ma6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ma6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6VT83_ARAHY Q6VT83_ARAHY] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The incidence of peanut allergy continues to rise in the United States and Europe. Whereas exposure to the major allergens Ara h 1, 2, 3, and 6 can cause fatal anaphylaxis, exposure to the minor allergens usually does not. Ara h 8 is a minor allergen. Importantly, it is the minor food allergens that are thought to be responsible for oral allergy syndrome (OAS), in which sensitization to airborne allergens causes a Type 2 allergic reaction to ingested foods. Furthermore, it is believed that similar protein structure rather than a similar linear sequence is the cause of OAS. Bet v 1 from birch pollen is a common sensitizing agent, and OAS results when patients consume certain fruits, vegetables, tree nuts, and peanuts. Here, we report the three-dimensional structure of Ara h 8, a Bet v 1 homolog. The overall fold is very similar to that of Bet v 1, Api g 1 (celery), Gly m 4 (soy), and Pru av 1 (cherry). Ara h 8 binds the isoflavones quercetin and apigenin as well as resveratrol avidly.

Structure and Function of the Peanut Panallergen Ara h 8.,Hurlburt BK, Offermann LR, McBride JK, Majorek KA, Maleki SJ, Chruszcz M J Biol Chem. 2013 Dec 27;288(52):36890-901. doi: 10.1074/jbc.M113.517797. Epub, 2013 Nov 19. PMID:24253038<ref>PMID:24253038</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ma6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arachis hypogaea]]
[[Category: Large Structures]]
[[Category: Chruszcz M]]
[[Category: Hurlburt BK]]
[[Category: Majorek KA]]
[[Category: Maleki SJ]]
[[Category: McBride JK]]
[[Category: Offermann LR]]