View source for 4mbq


==TPR3 of FimV from P. aeruginosa (PAO1)==
<StructureSection load='4mbq' size='340' side='right'caption='[[4mbq]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mbq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MBQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.006&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbq OCA], [https://pdbe.org/4mbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mbq RCSB], [https://www.ebi.ac.uk/pdbsum/4mbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mbq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FIMV_PSEAE FIMV_PSEAE] Inner membrane hub protein that plays both cAMP-dependent and cAMP-independent roles in twitching motility (PubMed:27297880, PubMed:28583947). Regulates intracellular cyclic AMP (cAMP) levels through the activation of adenylate cyclase CyaB (PubMed:20345659). Plays an essential role in a number of virulence mechanisms including type IV pilus (T4P)-mediated assembly and twitching motility as well as cAMP-dependent virulence gene expression (PubMed:21097635, PubMed:10846211). Mediates also type II secretion (T2S) of lipases and proteases (PubMed:21527471). In addition, mediates the cAMP-independent localization of multiple T4P structural and regulatory components to the cell poles (PubMed:21527471, PubMed:27297880, PubMed:28583947). This role in directing proteins to the cell pole is not restricted to type IV component and involves other proteins such as the diguanylate cyclase DgcP (By similarity).[UniProtKB:A0A0H2ZC68]<ref>PMID:10846211</ref> <ref>PMID:20345659</ref> <ref>PMID:21097635</ref> <ref>PMID:21527471</ref> <ref>PMID:27297880</ref> <ref>PMID:28583947</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Burrows LL]]
[[Category: Daniel-Ivad M]]
[[Category: Howell PL]]
[[Category: Junop MS]]
[[Category: Nguyen Y]]
[[Category: Robinson H]]
[[Category: Sugiman-Marangos SN]]
[[Category: Wolfram F]]
[[Category: Zhang K]]