View source for 4mhl


==The crystal structure of human interleukin-11==
<StructureSection load='4mhl' size='340' side='right'caption='[[4mhl]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mhl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MHL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARF:FORMAMIDE'>ARF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mhl OCA], [https://pdbe.org/4mhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mhl RCSB], [https://www.ebi.ac.uk/pdbsum/4mhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mhl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IL11_HUMAN IL11_HUMAN] Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Interleukin (IL)-11 is a multifunctional member of the IL-6 family of cytokines. Recombinant human IL-11 is administered as a standard clinical treatment for chemotherapy-induced thrombocytopaenia. Recently, a new role for IL-11 signalling as a potent driver of gastrointestinal cancers has been identified, and it has been demonstrated to be a novel therapeutic target for these diseases. Here, the crystal structure of human IL-11 is reported and the structural resolution of residues previously identified as important for IL-11 activity is presented. While IL-11 is thought to signal via a complex analogous to that of IL-6, comparisons show important differences between the two cytokines and it is suggested that IL-11 engages GP130 differently to IL-6. In addition to providing a structural platform for further study of IL-11, these data offer insight into the binding interactions of IL-11 with each of its receptors and the structural mechanisms underlying agonist and antagonist variants of the protein.

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6.,Putoczki TL, Dobson RC, Griffin MD Acta Crystallogr D Biol Crystallogr. 2014 Sep 1;70(Pt 9):2277-85. doi:, 10.1107/S1399004714012267. Epub 2014 Aug 23. PMID:25195742<ref>PMID:25195742</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4mhl" style="background-color:#fffaf0;"></div>

==See Also==
*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Griffin MDW]]