View source for 4mhu


==Crystal structure of EctD from S. alaskensis with bound Fe==
<StructureSection load='4mhu' size='340' side='right'caption='[[4mhu]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mhu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingopyxis_alaskensis_RB2256 Sphingopyxis alaskensis RB2256]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MHU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D9G:N-DODECYL-N,N-DIMETHYLGLYCINATE'>D9G</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mhu OCA], [https://pdbe.org/4mhu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mhu RCSB], [https://www.ebi.ac.uk/pdbsum/4mhu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mhu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ECTD_SPHAL ECTD_SPHAL] Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.<ref>PMID:24714029</ref> <ref>PMID:25172507</ref> 

==See Also==
*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sphingopyxis alaskensis RB2256]]
[[Category: Bremer E]]
[[Category: Heider J]]
[[Category: Hoeppner A]]
[[Category: Pittelkow M]]
[[Category: Smits SH]]
[[Category: Widderich N]]