View source for 4mhv


==Crystal structure of the PNT domain of human ETS2==
<StructureSection load='4mhv' size='340' side='right'caption='[[4mhv]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mhv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MHV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mhv OCA], [https://pdbe.org/4mhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mhv RCSB], [https://www.ebi.ac.uk/pdbsum/4mhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mhv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ETS2_HUMAN ETS2_HUMAN] Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.<ref>PMID:11909962</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Burgess-brown N]]
[[Category: Cooper CDO]]
[[Category: Edwards A]]
[[Category: Gileadi O]]
[[Category: Krojer T]]
[[Category: Newman JA]]
[[Category: Shrestha L]]