View source for 4mjj


==Crystal structure of the C2A domain of DOC2A==
<StructureSection load='4mjj' size='340' side='right'caption='[[4mjj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mjj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MJJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mjj OCA], [https://pdbe.org/4mjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mjj RCSB], [https://www.ebi.ac.uk/pdbsum/4mjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mjj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOC2A_HUMAN DOC2A_HUMAN] Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.<ref>PMID:9736751</ref> <ref>PMID:9804756</ref> <ref>PMID:18354201</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Huang QQ]]