View source for 4nbl


==Tailoring Small Molecules for an Allosteric Site on Procaspase-6==
<StructureSection load='4nbl' size='340' side='right'caption='[[4nbl]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NBL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.756&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2J6:5-FLUORO-2-({[3-(PYRIMIDIN-2-YL)PYRIDIN-2-YL]AMINO}METHYL)PHENOL'>2J6</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nbl OCA], [https://pdbe.org/4nbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nbl RCSB], [https://www.ebi.ac.uk/pdbsum/4nbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nbl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

==See Also==
*[[Caspase 3D structures|Caspase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Murray JM]]
[[Category: Steffek M]]