View source for 4nem


==Small molecular fragment bound to crystal contact interface of Interleukin-2==
<StructureSection load='4nem' size='340' side='right'caption='[[4nem]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NEM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.934&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2JY:5-[(2,3-DICHLOROPHENOXY)METHYL]FURAN-2-CARBOXYLIC+ACID'>2JY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nem OCA], [https://pdbe.org/4nem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nem RCSB], [https://www.ebi.ac.uk/pdbsum/4nem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nem ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
== Function ==
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

==See Also==
*[[Interleukin 3D structures|Interleukin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Allen KN]]
[[Category: Brenke R]]
[[Category: Jehle S]]
[[Category: Kozakov D]]
[[Category: Vajda S]]