View source for 4nnd


==Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites==
<StructureSection load='4nnd' size='340' side='right'caption='[[4nnd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nnd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NND FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nnd OCA], [https://pdbe.org/4nnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nnd RCSB], [https://www.ebi.ac.uk/pdbsum/4nnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nnd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN18_HUMAN PTN18_HUMAN] Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

==See Also==
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Du Y]]
[[Category: Wang H]]
[[Category: Yang D]]
[[Category: Yang F]]