View source for 4oaj


==Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptide==
<StructureSection load='4oaj' size='340' side='right'caption='[[4oaj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4oaj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OAJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oaj OCA], [https://pdbe.org/4oaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oaj RCSB], [https://www.ebi.ac.uk/pdbsum/4oaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oaj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DLG1_MOUSE DLG1_MOUSE] Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels (By similarity). Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.<ref>PMID:11238884</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Rattus norvegicus]]
[[Category: Dorr L]]
[[Category: Lian L-Y]]
[[Category: Mayans O]]
[[Category: Pandalaneni S]]