View source for 4odb


==Crystal structure of the T1L reovirus attachment protein sigma1 in complex with Junctional Adhesion Molecule-A==
<StructureSection load='4odb' size='340' side='right'caption='[[4odb]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4odb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1_Lang Mammalian orthoreovirus 1 Lang]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ODB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odb OCA], [https://pdbe.org/4odb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4odb RCSB], [https://www.ebi.ac.uk/pdbsum/4odb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4odb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mammalian orthoreovirus 1 Lang]]
[[Category: Stehle T]]
[[Category: Stettner E]]