View source for 4oe7


==Crystal structure of YagE, a KDG aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal==
<StructureSection load='4oe7' size='340' side='right'caption='[[4oe7]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4oe7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OE7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GXP:(4S)-4-HYDROXY-2,5-DIOXOPENTANOIC+ACID'>GXP</scene>, <scene name='pdbligand=GXS:(4R)-4-HYDROXY-2,5-DIOXOPENTANOIC+ACID'>GXS</scene>, <scene name='pdbligand=GXT:ETHANEDIAL'>GXT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oe7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oe7 OCA], [https://pdbe.org/4oe7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oe7 RCSB], [https://www.ebi.ac.uk/pdbsum/4oe7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oe7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YAGE_ECOLI YAGE_ECOLI] Catalyzes the formation of 2-keto-3-deoxy-galactonate (KDGal) from pyruvate and glyceraldehyde. Overexpression leads to increased growth (over 2 hours) in the presence of the antibiotics norfloxacin, ampicillin and streptomycin.
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</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Baskar V]]
[[Category: Krishnaswamy S]]
[[Category: Manicka S]]
[[Category: Manoj Kumar P]]