View source for 4ofn


==Monoclinic NaGST1==
<StructureSection load='4ofn' size='340' side='right'caption='[[4ofn]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ofn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Necator_americanus Necator americanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OFN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ofn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofn OCA], [https://pdbe.org/4ofn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ofn RCSB], [https://www.ebi.ac.uk/pdbsum/4ofn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ofn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D3U1A5_NECAM D3U1A5_NECAM] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Glutathione S-transferase 1 from Necator americanus (Na-GST-1) is a vaccine candidate for hookworm infection that has a high affinity for heme and metal porphyrins. As part of attempts to clarify the mechanism of heme detoxification by hookworm GSTs, co-crystallization and soaking studies of Na-GST-1 with the heme-like molecules protoporphyrin IX disodium salt, hematin and zinc protoporphyrin were undertaken. While these studies did not yield the structure of the complex of Na-GST-1 with any of these molecules, co-crystallization experiments resulted in the first structures of the complex of Na-GST-1 with the substrate glutathione. The structures of the complex of Na-GST-1 with glutathione were solved from pathological crystalline aggregates comprising more than one crystal form. These first structures of the complex of Na-GST-1 with the substrate glutathione were solved by molecular replacement from data collected with a sealed-tube home source using the previously reported apo structure as the search model.

Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione.,Asojo OA, Ceccarelli C Acta Crystallogr F Struct Biol Commun. 2014 Sep;70(Pt 9):1162-6. doi:, 10.1107/S2053230X1401646X. Epub 2014 Aug 29. PMID:25195885<ref>PMID:25195885</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ofn" style="background-color:#fffaf0;"></div>

==See Also==
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Necator americanus]]
[[Category: Asojo OA]]