View source for 4ofq


==Structure of the C-terminal domain of the Streptococcus pyogenes antigen I/II-family protein AspA==
<StructureSection load='4ofq' size='340' side='right'caption='[[4ofq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ofq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_MGAS6180 Streptococcus pyogenes MGAS6180]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OFQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ofq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofq OCA], [https://pdbe.org/4ofq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ofq RCSB], [https://www.ebi.ac.uk/pdbsum/4ofq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ofq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q48S75_STRPM Q48S75_STRPM] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The pathogenic bacteria Streptococcus pyogenes can cause an array of diseases in humans, including moderate infections such as pharyngitis (strep throat) as well as life threatening conditions such as necrotizing fasciitis and puerperal fever. The antigen I/II family proteins are cell wall anchored adhesin proteins found on the surfaces of most oral streptococci and are involved in host colonization and biofilm formation. In the present study we have determined the crystal structure of the C2-3-domain of the antigen I/II type protein AspA from S. pyogenes M type 28. The structure was solved to 1.8 A resolution and shows that the C2-3-domain is comprised of two structurally similar DEv-IgG motifs, designated C2 and C3, both containing a stabilizing covalent isopeptide bond. Furthermore a metal binding site is identified, containing a bound calcium ion. Despite relatively low sequence identity, interestingly, the overall structure shares high similarity to the C2-3-domains of antigen I/II proteins from Streptococcus gordonii and Streptococcus mutans, although certain parts of the structure exhibit distinct features. In summary this work constitutes the first step in the full structure determination of the AspA protein from S. pyogenes.

Structure of the C-terminal domain of AspA (antigen I/II-family) protein from Streptococcus pyogenes.,Hall M, Nylander S, Jenkinson HF, Persson K FEBS Open Bio. 2014 Mar 12;4:283-9. doi: 10.1016/j.fob.2014.02.012. eCollection, 2014. PMID:24918040<ref>PMID:24918040</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ofq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus pyogenes MGAS6180]]
[[Category: Hall M]]
[[Category: Jenkinson HF]]
[[Category: Nylander A]]
[[Category: Persson K]]