View source for 4oia


==Crystal Structure of ICAM-5 D1-D4 ectodomain fragment, Space Group P4322==
<StructureSection load='4oia' size='340' side='right'caption='[[4oia]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4oia]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OIA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oia OCA], [https://pdbe.org/4oia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oia RCSB], [https://www.ebi.ac.uk/pdbsum/4oia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oia ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ICAM5_HUMAN ICAM5_HUMAN] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Intercellular cell adhesion molecule-5 (ICAM-5) is a member of the ICAM subfamily that is exclusively expressed in the telencephalon region of the brain. The crystal structure of the four most N-terminal glycosylated domains (D1-D4) of ICAM-5 was determined in three different space groups and the D1-D5 fragment was modelled. The structures showed a curved molecule with two pronounced interdomain bends between D2 and D3 and between D3 and D4, as well as some interdomain flexibility. In contrast to ICAM-1, ICAM-5 has patches of positive and negative electrostatic charge at D1-D2 and at D3-D5, respectively. ICAM-5 can mediate homotypic interactions. In the crystals, several charge-based intermolecular interactions between the N-terminal and C-terminal moieties of the ICAM-5 molecules were observed, which defined an interacting surface in the D1-D4 fragment. One of the crystal lattices has a molecular assembly that could represent the homophilic ICAM-5 cell adhesion complex in neurons.

Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions.,Recacha R, Jimenez D, Tian L, Barredo R, Gahmberg CG, Casasnovas JM Acta Crystallogr D Biol Crystallogr. 2014 Jul 1;70(Pt 7):1934-43. doi:, 10.1107/S1399004714009468. Epub 2014 Jun 29. PMID:25004970<ref>PMID:25004970</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4oia" style="background-color:#fffaf0;"></div>

==See Also==
*[[Intercellular adhesion molecule|Intercellular adhesion molecule]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Barredo R]]
[[Category: Casasnovas JM]]
[[Category: Ghamberg C]]
[[Category: Jimenez D]]
[[Category: Recacha R]]
[[Category: Tian L]]