View source for 4ojz


==Crystal Structure of Alg17c Mutant Y258A Complexed with Alginate Trisaccharide==
<StructureSection load='4ojz' size='340' side='right'caption='[[4ojz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ojz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharophagus_degradans_2-40 Saccharophagus degradans 2-40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OJZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEM:BETA-D-MANNURONIC+ACID'>BEM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LGU:ALPHA-L-GULURONATE'>LGU</scene>, <scene name='pdbligand=MAV:ALPHA-D-MANNOPYRANURONIC+ACID'>MAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ojz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ojz OCA], [https://pdbe.org/4ojz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ojz RCSB], [https://www.ebi.ac.uk/pdbsum/4ojz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ojz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EALGL_SACD2 EALGL_SACD2] Catalyzes the depolymerization of alginate through an exolytic mode of action, via a beta-elimination mechanism. Preferentially acts on oligoalginates with degrees of polymerization higher than 2 to produce the alginate monomer, 4-deoxy-L-erythro-5-hexoseulose uronic acid.<ref>PMID:22281843</ref> <ref>PMID:24478312</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharophagus degradans 2-40]]
[[Category: Nair SK]]
[[Category: Park DS]]