View source for 4oys


==CRYSTAL STRUCTURE OF VPS34 IN COMPLEX WITH SAR405.==
<StructureSection load='4oys' size='340' side='right'caption='[[4oys]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4oys]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1TT:(8S)-9-[(5-CHLORANYLPYRIDIN-3-YL)METHYL]-2-[(3R)-3-METHYLMORPHOLIN-4-YL]-8-(TRIFLUOROMETHYL)-6,7,8,9A-TETRAHYDRO-3H-PYRIMIDO[1,2-A]PYRIMIDIN-4-ONE'>1TT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oys OCA], [https://pdbe.org/4oys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oys RCSB], [https://www.ebi.ac.uk/pdbsum/4oys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oys ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> 

==See Also==
*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Marquette Jp]]
[[Category: Mathieu M]]