View source for 4pe2


==MBP PilA1 CD160==
<StructureSection load='4pe2' size='340' side='right'caption='[[4pe2]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4pe2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile_CD160 Clostridioides difficile CD160] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PE2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.724&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pe2 OCA], [https://pdbe.org/4pe2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pe2 RCSB], [https://www.ebi.ac.uk/pdbsum/4pe2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pe2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/T3D4G1_CLODI T3D4G1_CLODI] 
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== Publication Abstract from PubMed ==
Type IV pili are produced by many pathogenic Gram-negative bacteria and are important for processes as diverse as twitching motility, biofilm formation, cellular adhesion, and horizontal gene transfer. However, many Gram-positive species, including Clostridium difficile, also produce type IV pili. Here, we identify the major subunit of the type IV pili of C. difficile, PilA1, and describe multiple 3D structures of PilA1, demonstrating the diversity found in three strains of C. difficile. We also model the incorporation of both PilA1 and a minor pilin, PilJ, into the pilus fiber. Although PilA1 contains no cysteine residues, and therefore cannot form the disulfide bonds found in all Gram-negative type IV pilins, it adopts unique strategies to achieve a typical pilin fold. The structures of PilA1 and PilJ exhibit similarities with the type IVb pilins from Gram-negative bacteria that suggest that the type IV pili of C. difficile are involved in microcolony formation.

Structural and Evolutionary Analyses Show Unique Stabilization Strategies in the Type IV Pili of Clostridium difficile.,Piepenbrink KH, Maldarelli GA, Martinez de la Pena CF, Dingle TC, Mulvey GL, Lee A, von Rosenvinge E, Armstrong GD, Donnenberg MS, Sundberg EJ Structure. 2015 Feb 3;23(2):385-96. doi: 10.1016/j.str.2014.11.018. Epub 2015 Jan, 15. PMID:25599642<ref>PMID:25599642</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4pe2" style="background-color:#fffaf0;"></div>

==See Also==
*[[Maltose-binding protein 3D structures|Maltose-binding protein 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Clostridioides difficile CD160]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Piepenbrink KH]]
[[Category: Sundberg EJ]]