View source for 4pp4


==Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication==
<StructureSection load='4pp4' size='340' side='right'caption='[[4pp4]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4pp4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_minute_virus_strain_MVM_prototype Murine minute virus strain MVM prototype]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PP4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pp4 OCA], [https://pdbe.org/4pp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pp4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pp4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NS1_MUMIP NS1_MUMIP] Multifunctional protein that plays an essential role in viral DNA replication. Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition. These arrests may provide essential cellular factors for viral DNA replication. Interacts specifically with the viral DNA origin of replication and plays a direct role in DNA replication. Participates in the transcriptional regulation of several promoters including the viral p38 promoter that regulates the expression of VP1 and VP2 transcripts. Promotes apoptosis in host cell.<ref>PMID:11602746</ref> <ref>PMID:21295324</ref> <ref>PMID:7636987</ref> <ref>PMID:9188601</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Murine minute virus strain MVM prototype]]
[[Category: Tang L]]
[[Category: Tewary SK]]
[[Category: Zhao H]]