View source for 4pqj


==Crystal structure of a phosphate binding protein==
<StructureSection load='4pqj' size='340' side='right'caption='[[4pqj]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4pqj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PQJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqj OCA], [https://pdbe.org/4pqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pqj RCSB], [https://www.ebi.ac.uk/pdbsum/4pqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSTS_PSEAI PSTS_PSEAI] Binds 1 inorganic phosphate per subunit, required for phosphate transport (By similarity). In virulent strain MDR25, which expresses very high levels of this protein, implicated in host cell adhesion; antibody fragments against this protein decrease adhesion to host cells and increase transepithelial resistance of human epithelial cell monolayers. High-phosphate-grown MDR25 strains form smooth colonies, express less PstS, more biofilm and are less lethal in mouse infection models than high-phosphate-grown rough colonies that express more PstS, less biofilm and are more lethal in mouse infection models; whether this is phenotype is due to PstS is unknown, however feeding mice with phosphate supplements protects them from lethality. The ability of PstS to bind phosphate may allow it to acquire phosphate from its host (PubMed:18282104).[UniProtKB:G3XDA8]<ref>PMID:18282104</ref> 

==See Also==
*[[Phosphate-binding protein|Phosphate-binding protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Neznansky A]]
[[Category: Opatowsky Y]]